For a Blue Light Cystoscopy (BLC®) with Cysview® urologists use a cystoscope equipped with both white and blue light. Before the procedure Cysview is instilled into the bladder. Cysview is absorbed by the cancer cells and makes them fluoresce bright pink in blue light so they stand out against the blue of the healthy tissue.
During the procedure, when the urologist switches from white light to blue light, the fluorescence improves the detection of non-muscle invasive bladder cancer (NMIBC) lesions. Studies have found that there is a significant increase in the detection of NMIBC versus white light alone.1
Mechanism of Action Pathway2
Here’s what happens on the cellular level.
- After instillation in the bladder, Cysview interacts with the heme biosynthetic pathway.
- Selective intracellular accumulation of photoactive porphyrins (PAP) takes place.
- PAPs preferentially accumulate in rapidly proliferating neoplastic cells.
- After one hour, sufficient PAPs accumulate.
- Under subsequent blue light illumination, neoplastic cells fluoresce bright pink.
How Cysview (HAL) is metabolized in cancer cells
1 Cysview [prescribing Information]. 2018:1-14.
2 Wachoska M, Muchowicz A, et al. Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer. Molecules. 2011;16(5):4140-4164.