The Science/MOA | Cysview.com

The Science/MOA

MOA Video

Mechanism of Action Pathway²

Here’s what happens on the cellular level.

After instillation in the bladder, Cysview interacts with the heme biosynthetic pathway.
Selective intracellular accumulation of photoactive porphyrins (PAP) takes place.
PAPs preferentially accumulate in rapidly proliferating neoplastic cells.
After one hour, sufficient PAPs accumulate.
Under subsequent blue light illumination, neoplastic cells fluoresce bright pink.

How Cysview works to detect bladder cancer

How Cysview (HAL) is metabolized in cancer cells

¹Cysview[prescribing Information]. 2019:1-4.

²Wachoska M, Muchowicz A, et al. Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer. Molecules. 2011;16(5):4140-4164.

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Important Safety Information About Cysview^® (hexaminolevulinate HCl)

Cysview is not a replacement for random bladder biopsies or other procedures used in the detection of bladder cancer.

Anaphylactoid shock, hypersensitivity reactions, bladder pain, cystitis, and abnormal urinalysis have been reported after administration of Cysview. The most common adverse reactions seen in clinical trials were bladder spasm, dysuria, hematuria, and bladder pain.